GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus.

Brain Res.2003 Mar 28;967(1-2):285-9

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Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-concentrating hormone (MCH) peptides, whereas occasional co-expression (<10%) with cocaine-amphetamine-regulated transcript (CART) was found. Our results suggest that novel GABA(A) receptor subtypes comprising epsilon-subunit are important for metabolic and neuroendocrine functions.

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GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus.

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