SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold.
Curr. Opin. Struct. Biol.2002 Dec;12(6):783-93
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摘要
The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind the common cofactor are poorly conserved, although the binding site is localised to the same region of the fold. The substrate-binding region of the fold varies enormously. Over the past two years, there has been a significant increase in the number of structures that are known to incorporate this fold, including several uncharacterized proteins and two proteins that lack methyltransferase activity.
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基因功能
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原始数据
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文献解读
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