[No authors listed]
The unfolded protein response (UPR) counteracts stress caused by unprocessed ER client proteins. A genome-wide survey showed impaired induction of many UPR target genes in xbp-1 mutant Caenorhabditis elegans that are unable to signal in the highly conserved IRE1-dependent UPR pathway. However a family of genes, abu (activated in blocked UPR), was induced to higher levels in ER-stressed xbp-1 mutant animals than in ER-stressed wild-type animals. RNA-mediated interference inactivation of a representative abu family member, abu-1 (AC3.3), activated the ER stress marker hsp-4::gfp in otherwise normal animals and killed 50% of ER-stressed ire-1 and xbp-1 mutant animals. also enhanced the effect of inactivation of sel-1, an ER-associated protein degradation gene. The nine abu genes encode highly related type I transmembrane proteins whose lumenal domains have sequence similarity to a mammalian cell surface scavenger receptor of endothelial cells that binds chemically modified extracellular proteins and directs their lysosomal degradation. Our findings that ABU-1 is an intracellular protein located within the endomembrane system that is induced by ER stress in xbp-1 mutant animals suggest that ABU proteins may interact with abnormal ER client proteins and this function may be particularly important in animals with an impaired UPR.
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hsp-70, abu-11, hsp-4, ckb-2, C14B9.2, dsc-4, col-109, D2096.6, bre-1, pqn-74, hsp-16.41, abu-6, abu-8, srp-7, F41E6.11, hsp-16.1, hsp-16.48, hsp-16.49, hsp-16.11, T06E4.8, F53B1.4, pdi-2, hsp-3, F41B4.3, pdi-6, dnj-7, lec-8, T14G8.3, lin-15B, abu-1, abu-7, abu-2, abu-3, abu-10, pqn-57, Y41C4A.11, abu-5, arf-1.1, gad-3, cdr-4, abu-4
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