Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma.

Differential display-polymerase chain reaction was used to compare gene expression between human chondrosarcoma cell lines and normal cartilage. A new gene, has been cloned and belongs to a gene family that includes the taxol resistance associated gene (TRAG)-3. Cduanyu1798, like TRAG-3, does not confer resistance to taxol when transfected in vitro. Both genes have alternatively spliced variants. and TRAG-3 are expressed in chondrosarcoma, melanoma, and cartilage and testis, but not in other normal tissues. TRAG-3 has been reported to be a cancer/testis antigen. Our results suggest that Cduanyu1798 belongs to the growing list of cancer/testis antigens as well. In all of the Cduanyu1798 positive samples, the melanoma antigen gene family was also expressed. This is the first report on the expression of cancer/testis antigens in chondrosarcoma.

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