Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons.

The endoplasmic reticulum (ER) is divided into rough and smooth domains and SER). The two domains share most proteins, but is enriched in some membrane proteins by an unknown mechanism. We studied duanyu1795 protein targeting by expressing fluorescent protein fusions to ER membrane proteins in Caenorhabditis elegans. In several cell types duanyu1795 and general ER proteins colocalized, but in neurons duanyu1795 proteins were concentrated in the cell body, whereas general ER proteins were also found in neurites. Surprisingly duanyu1795 membrane proteins diffused rapidly within the cell body, indicating they are not localized by immobilization. Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting duanyu1795 membrane proteins.

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