A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?
Trends Biochem. Sci.2002 Mar;27(3):115-7
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摘要
A new subfamily of two-domain histone acetyltransferases (HATs) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical enzymes. Two-domain organization is preserved in evolution, suggesting that both enzymatic activities are functionally or mechanistically coupled and directed towards highly conserved substrates. The functional implications of this similarity and a possible role for Elp3-related proteins as histone demethylases are discussed.
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基因功能
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原始数据
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文献解读
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