Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

Biochem. Biophys. Res. Commun.2002 Jan 11;290(1):452-6

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A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.

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Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

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