The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.
Bioorg. Med. Chem. Lett.2001 Sep 03;11(17):2245-8
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摘要
The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.
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基因功能
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原始数据
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文献解读
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