例如:"lncRNA", "apoptosis", "WRKY"

Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

Genes Dev.2000 Jul 15;14(14):1741-9
K Tago 1 , T Nakamura , M Nishita , J Hyodo , S Nagai , Y Murata , S Adachi , S Ohwada , Y Morishita , H Shibuya , T Akiyama
K Tago 1 , T Nakamura , M Nishita , J Hyodo , S Nagai , Y Murata , S Adachi , S Ohwada , Y Morishita , H Shibuya , T Akiyama
+ et al

[No authors listed]

Author information
  • 1 Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan.

摘要


Wnt signaling has an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Here, we identify a novel beta-catenin-interacting protein, ICAT, that was found to inhibit the interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated transactivation. Furthermore, ICAT inhibited Xenopus axis formation by interfering with Wnt signaling. These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between beta-catenin and TCF and is integral in development and cell proliferation.