SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.

Proc. Natl. Acad. Sci. U.S.A.2000 Jul 05;97(14):7877-81

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LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell-cell interactions during development. The sel-8 gene had been identified previously in a screen for suppressors of a mutation that constitutively activates LIN-12. Here, we report that sel-8 is essential for lin-12- and glp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein. We postulate that SEL-8 serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains.

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SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.

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