The mouse as a model for the effects of MHC genes on human disease.
Immunol. Today. 2000 Jul;21(7):328-32
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摘要
As mice are often used to model human major histocompatibility complex (MHC)-associated diseases, it is important to understand how their MHC regions differ at the DNA level. The sequencing of the mouse MHC (H2 region) has enabled a detailed map of this region to be assembled for comparison with the human MHC. Here, Richard Allcock and colleagues outline the similarities between the human and mouse MHC regions and discuss notable differences that might affect disease models.
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基因功能
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原始数据
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文献解读
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