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Chronic prenatal cocaine treatment down-regulates mu-opioid receptor mRNA expression in the brain of fetal Rhesus Macaque.

Neurosci. Lett.1999 Feb 12;261(1-2):45-8
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摘要


Ribonuclease protection assays (RPA) were performed to quantify mu-opioid receptor mRNA expression in specific brain regions of day 70 Rhesus Macaque fetuses that were exposed to cocaine (3 mg/kg) or saline from days 22-70 of gestation. The content of mu-receptor mRNA was high in the diencephalon and moderate in the mesencephalon. In contrast, mu-receptor mRNA was lightly expressed in areas such as the frontal cortex, striatum and the temporal lobe. The content of mu-opioid receptor mRNA was significantly higher in the diencephalon than in other brain regions (P < 0.001; n = 4). Cocaine exposure significantly decreased the expression of mu-receptor mRNA in the fetal diencephalon (P < 0.05; n = 4 in each group). Our data would indicate that prolonged gestational cocaine exposure causes mu-opioid receptor mRNA down-regulation in specific brain regions of the fetus.

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